This book is designed to provide a concise yet comprehensive summary of the traditional and new definitions prognostic markers the pathobiology and newer hierarchal classification based on molecular genetics chromosomal abnormalities. Chronic lymphocytic leukemia cll is a neoplasm composed of small monomor phic round to slightly irregular b lymphocytes in the peripheral blood bone marrow spleen and lymph nodes. Note citations are based on reference standards however formatting rules can vary widely between applications and fields of interest or study the specific requirements or preferences of your reviewing publisher classroom teacher institution or organization should be applied. Chronic lymphocytic leukemia is a type of cancer in which the bone marrow makes too many lymphocytes a type of white blood cell leukemia may affect red blood cells white blood cells and platelets older age can affect the risk of developing chronic lymphocytic leukemia. Introduction chronic lymphocytic leukemia cll is common hematologic disease in western societies with over 15000 patients were diagnosed annually but is very rare in asian cohorts as well as koreathe molecular diagnostic tools and variable understanding of the pathobiology of the disease have facilitated characterization of variations in the diseases clinical course resulting in
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